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pentobarbital will lower the extent or result of lefamulin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Steer clear of coadministration of lefamulin with potent or moderate CYP3A inducers Except if the gain outweighs hazards. Observe for decreased efficacy.pentobarbital will lower the level or ef